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Dr. Ramachandra S. Hosmane
RESEARCH PUBLICATIONS
160. G. Bol, F. Vesuna, M. Xie, J. Zeng, K. Aziz, N. Gandhi, A. Levine, A. Irving, D. Korz, S. Tantravedi, M. H. van Voss, K. Gabrielson, E. Bordt, B. Polster, L. Cope, P. van der Groep, A. Kondaskar, M. Rudek-Renaut, E. van der Wall, P. Van Diest, P. Tran, R. Hosmane, and V. Raman, " Targeting DDX3 by a Small Molecule Inhibitor for Lung Cancer Therapy," 2017, 7, 648-669.
159. N. Zhang, P. Zhang, A. Baier, L. Cova, and R. S. Hosmane, "Dual Inhibition of HCV and HIV by Ring-Expanded Nucleosides Containing the 5:7-Fused Imidazo[4,5-e][1,3]diazepine Ring System. In Vitro Results and Implications," Bioorg. Med. Chem. Lett. 2014, 24, 1154-1157.
158. S. Tantravedi, S. Chakraborty, J. C. Fishbein, and R. S. Hosmane, “Analogs of Iso-Azepinomycin as Potential Transition-State Analog Inhibitors of Guanase: Synthesis, Biochemical Screening, and Structure-Activity Correlations of Various Selectively Substituted Imidazo[4,5-e][1,4]diazepines,” Bioorg. Med. Chem. 2013, 21, 4893-4903.
157. A. Kondaskar, S. Kondaskar, J. C. Fishbein, B. A. Carter-Cooper, R. G. Lapidus, M. Sadowska, M. J. Edelman, and R. S. Hosmane, "Structure-based Drug Design and Potent Anti-cancer Activity of Tricyclic 5:7:5-Fused Diimidazo[4,5-d:4',5'-f][1,3]diazepines," Bioorg. Med. Chem. 2013, 21, 618-631.
156. S. Chakraborty, N. H. Shah, J. C. Fishbein, and R. S. Hosmane, "Investigations into Specificity of Azepinomycin for Inhibition of Guanase: Discrimination between the Natural Heterocyclic Inhibitor and Its Synthetic Nucleoside Analogues," Bioorg. Med. Chem. Lett. 2012, 22, 7214-7218.
155. S. Chakraborty, N. H. Shah, J. C. Fishbein, and R. S. Hosmane, “A Novel Transition State Analogue Inhibitor of Guanase Based on Azepinomycin Ring Structure: Synthesis and Biochemical Assessment of Enzyme Inhibition,” Bioorg. Med. Chem. Lett. 2011, 21, 756-759.
154. A. Kondaskar, S. Kondaskar, R. Kumar, N. Muvarak, R. G. Lapidus, M. Sadowska, M. J. Edelman, G. M. Bol, V. Raman, and R. S. Hosmane, “Novel, Broad Spectrum Anti-Cancer Agents Containing the Tricyclic 5:7:5-Fused Diimidazodiazepine Ring System,” ACS Med Chem. Lett. 2011, 2, 252-256.
153. H. Cai, T. A. Roach, M. Dabek, K. S. Somerville, S. Acharya, and R. S. Hosmane, “Bis[2-(3-carboxyphenoxy)carbonylethyl]phosphinic Acid (m-BCCEP): A Novel Affinity Cross-Linking Reagent for the -Cleft Modification of Hemoglobin,” Bioconj. Chem. 2010, 21, 1494-1507.
152. M. Xie, R. K. Ujjinamatada, M. Sadowska, R. G. Lapidus, M. J. Edelman, and R. S. Hosmane, “A Novel, Broad-Spectrum Anticancer Compound Containing the Imidazo[4,5-e][1,3]diazepine Ring System,” Bioorg. Med. Chem. Lett. 2010, 20, 4386-4389.
151. K. Watashi, M. L. Yeung, M. F. Starost, R. S. Hosmane, and K. –T. Jeang, “Identification of Small Molecules that Suppress Micro RNA Function and Reverse Tumorigenesis,” J. Biol. Chem. 2010, 285, 24707-24716.
150. R. S. Hosmane and J. F. Liebman, "Paradoxes and Paradigms: Why is Quinoline Less Basic than Pyridine or Isoquinoline? A Classical Organic Chemical Perspective,” Struct. Chem. 2009, 20, 693-697.
149. R. S. Hosmane, "Ring-Expanded ("Fat") Purines and Their Nucleoside/Nucleotide Analogues as Broad-Spectrum Therapeutics, ” Progr. Heterocycl. Chem. 2009, 21, 35-68.
148. R. Kumar, R. K. Ujjinamatada, and R. S. Hosmane ” The First Synthesis of a Novel 5:7:5-Fused Diimidazodiazepine Ring System and Some of Its Chemical Properties, ” Org. Lett., 10, 4681-4684 (2008).
147. V. Yedavalli, N. Zhang, H. Cai, K. –T. Jeang, and R. S. Hosmane, “Ring-Expanded Nucleosides (RENs) Exhibit Potent In Vitro Anti-HIV Activity with Little or No Toxicity in ex vivo Cell Culture and in vivo in Mice. Synthesis and Mechanistic Explorations,” J. Med. Chem., 51, 5043-5051
(2008).
R. K. Ujjinamatada, P. Phatak, A. M. Burger, and R. S. Hosmane, “Inhibition of adenosine deaminase by analogues of adenosine and inosine incorporating a common heterocyclic base, 4(7)-amino-6(5)H-imidazo[4,5-d]pyridazin-7(4)one,” J. Med. Chem., 51, 694-698 (2008).
145. P. Zhang, N. Zhang, V. Buckwold, R. S. Hosmane, “Chemical and biological effects of substitution of the 2-position of ring-expanded (“fat”) nucleosides containing the imidazo[4,5-e][1,3] diazepine-4,8-dione ring system: The role of electronic and steric factors on glycosidic bond stability and anti-HCV activity,” Bioorg. Med. Chem., 15, 4933-4955 (2007).
144. R. K. Ujjinamatada, A. Baier, P. Borowski, and R. S. Hosmane, 'An analogue of AICAR with dual inhibitory activity against WNV and HCV NTPase/helicase: Synthesis and in vitro screening of 4-carbamoyl-5-(4,6-diamino-2,5-dihydro-1,3,5-triazin-2-yl)imidazole-1-ß-D-ribofuranoside,' Bioorg. Med. Chem. Lett., 17, 2285-2288 (2007).
143. P. Zhang, N. Zhang, B. E. Korba, and R. S. Hosmane, “Structure-Activity Relationship Studies on Anti-HCV Activity of Ring-Expanded “Fat”)Nucleobase Analogues Containing the Imidazo[4,5-e][1,3]diazepine Ring System,” Bioorg. Med. Chem. Lett., 17, 2225-2228 (2007).
142. R. K. Ujjinamatada, A. Bhan, and R. S. Hosmane, "Design of Inhibitors Against Guanase: Synthesis and Biochemical Evaluation of Analogues of Azepinomycin," Bioorg. Med. Chem. Lett., 16, 5551-5554 (2006).
141. Ravi K. Ujjinamatada, Robin L. Paulman, Roger G. Ptak, and Ramachandra S. Hosmane, “Nucleosides with Self- Complementary Hydrogen-Bonding Motifs: Synthesis and Base-Pairing Studies of Two Nucleosides Containing the Imidazo[4,5-d]pyridazine Ring System” Bioorg. Med. Chem., 14, 6359-6367 (2006).
140. P. Zhang, N. Zhang, B. E. Korba, and R. S. Hosmane, “Synthesis and In Vitro Anti-Hepatitis B and C Virus Activities of Ring-Expanded ("Fat") Nucleobase Analogues Containing the Imidazo[4,5-e][1,3]diazepine-4,8-dione Ring System,” Bioorg. Med. Chem. Lett., 15, 5397-5401 (2005).
139. R. K. Ujjinamatada and R. S. Hosmane, “Selective Functional Group Transformation Using Guanidine: The Conversion of an Ester Group into an Amide in Vinylogous Ester-Aldehydes,” Tetrahedron Lett., 46, 6005-6009 (2005).
138. R. K. Ujjinamatada, Y. S. Agasimundin, P. Zhang, V. Koch, H. Schmitz, P. Borowski, K. Kalicharran, A. Fattom, and R. S. Hosmane, “A Novel Imidazole Nucleoside Containing a Diaminodihydro-s-Triazine as a Substituent and an Inhibitory Activity against the West Nile Virus NTPase/Helicase,” Nucleosides Nucleotides Nucleic Acids, 24, 1775-1788 (2005).
137. R. K. Ujjinamatada, Y. S. Agasimundin, Y. S., P. Borowski, and R. S. Hosmane, “ Reactions of Guanidine with Vinylogous Ester-Aldehydes: Synthesis and Anti-West Nile Virus Activity of a Novel Imidazole Nucleoside Containing a Diaminodihydro-s-triazine as a Substituent,” Antiviral Res., 65, A68-A69 (2005).
136. T. A. Roach, V. W. Macdonald, and R. S. Hosmane, “A Novel Site-Directed Affinity Reagent for Cross-Linking Human Hemoglobin: Bis[2-(4-phosphonooxy phenoxy)carbonylethyl]phosphinic Acid (BPPCEP)” J. Med. Chem., 47, 5847- 5859 (2004).
135. S. Gunther, M. Asper, C. Röser, L. K. S. Luna, C. Drosten, B. Becker-Ziaja, P. Borowski, H. –M. Chen, and R.S. Hosmane, “Application of Real-Time PCR for Testing Antiviral Compounds Against Lassa Virus, SARS Corona Virus, and Ebola Virus In Vitro,” Antiviral Res., 63, 209-215 (2004).
134. R. S. Hosmane, “Antiviral Agents,” in Kirk-Othmer Encyclopedia of Chemical Technology (5th Edition), John Wiley & Sons, New York, Vol. 3, pp 135-182 (2004) (invited article).
133. A. Reayi and R. S. Hosmane, “Inhibition of Adenosine Deaminase by Novel 5:7-Fused Heterocycles Containing the Imidazo[4,5-e][1,2,4]triazepine Ring System: A Structure-Activity Relationship Study,” J. Med. Chem., 47, 1044-1050 (2004).
132. A. Reayi and R. S. Hosmane, "Inhibitors of Adenosine Deaminase: Continued Studies of Structure-Activity Relationships in Analogues of Coformycin," Nucleosides Nucleotides Nucleic Acids, 23, 263-270 (2004).
131. R. S. Hosmane and J. F. Liebman, “Resonance Stabilization in Diazophenoxides,” Struct. Chem., 15, 253-255 (2004).
130. N. Zhang, H.-M. Chen, V. Koch, H. Schmitz, C.-L. Liao, A. I. Fattom, R. B. Naso, K. Kalicharran, P. Borowski, and R. S. Hosmane, "Potent inhibition of NTPase/helicase of the West Nile Virus by Ring-Expanded Nucleoside (REN) Analogues,"
J. Med. Chem., 46, 4776 – 4789 (2003).
129. N. Zhang, H. –M. Chen, V. Koch, C-L. Liao, M. Bretner, V. S. Bhadti, A. I. Fattom, R. B. Naso, P. Borowski, and R. S. Hosmane, “Ring-Expanded (“fat”) Nucleoside and Nucleotide Analogues Exhibit Potent In Vitro Activity Against Flaviviridae NTPases/Helicases, including Those of the West Nile Virus (WNV), Hepatitis C Virus (HCV), and Japanese Encephalitis Virus (JEV),” J. Med. Chem., 46 , 4149-4164 (2003)
128. N. Zhang, H. -M. Chen, R. Sood, K. Kalicharran, A. I. Fattom, R. B. Naso, D. L. Barnard, R. W. Sidwell, and R. S. Hosmane, "In Vitro Inhibition of Measles Virus Replication by Novel Ring-Expanded (“Fat”) Nucleoside Analogues Containing the Imidazo[4,5-e][1,3]diazepine Ring System, Bioorg. Med. Chem. Lett. ,12, 3391-3394 (2002).
127. R. K. Sood, V. S. Bhadti, A. I. Fattom, R. B. Naso, H. Chen, B. E. Korba, E. Kern, and R. S. Hosmane, "Novel Ring-Expanded Nucleoside Analogs Exhibit Potent and Selective Inhibition of Hepatitis B Virus Replication in Cultured Human Hepatoblastoma Cells," Antiviral Res., 53, 159-164 (2002).
126. P. Borowski, M. Lang, A. Haag, H. Schmitz, J. Choe, H. ‑M. Chen, and R. S. Hosmane, “Characterization of Imidazo[4,5‑d]pyridazine Nucleosides as Modulators of Unwinding Reaction Mediated by West Nile Virus NTPase/Helicase: Evidence for Activity on the Level of Substrate and/or Enzyme,” Antimicrob. Agents Chemotherap., 46, 1231-1239 (2002).
125. F. N. Burnett and R. S. Hosmane, "Synthesis of a Novel Ring-Expanded Purine Analogue Containing a 5:8-Fused `Imidazo[4,5-e][1,2,4]triazocine Ring System Amidst Opportunistic Rearrangements and Ring Transformations," Tetrahedron, 58, 9567-9578 (2002).
124. R. Hosmane, "Ring-Expanded ("Fat") Nucleosides as Broad-Spectrum Anticancer and Antiviral Agents," in "Current Topics in Medicinal Chemistry: Recent Developments in Antiviral Nucleosides, Nucleotides, and Oligonucleotides," Hosmane, R. S., Ed., Bentham Science Publishers, Vol. 2, pp. 1093-1109 (2002).
123. R. Hosmane, "Coformycin and Analogues as Inhibitors of Adenosine Deaminase," in "Modified Nucleosides, Synthesis, and Applications," Loakes, D, Ed., Transworld Research Network, Trivendrum, pp.133-151 (2002).
122. P. Borowski, A. Niebuhr, H. Schmitz, R. S. Hosmane, M. Bretner, M. A. Siwecka, and T. Kulikowski, "NTPase/Helicase of
Flaviviridae: Inhibitors and Inhibition of the Enzyme," Acta Biochem. Polon., 49, 597-614 (2002).
121. M. V. Roux, M. Temprado, J. Z. Dávalos, P. Jiménez, R. S. Hosmane, and J. F. Liebman, "Enthalpy of Formation of Methyl
Benzoate: Calorimetry and Consequences," Phys. Chem. Chem. Phys., 4, 3611-3613 (2002).
120. R. S. Hosmane and J. F. Liebman, "Diazomethane and Ethyl Diazoacetate: The Role of Substituent Effects on Stability," Struct. Chem., 5-6, 501-503 (2002).
119. H. -M. Chen and R. S. Hosmane, "Synthesis of a Novel Ring-Expanded ("Fat") Nucleotide Analogue of Phosphonomethoxyethylguanine (PMEG) Containing the Imidazo[4,5-e][1,3]diazepine Ring System," J. Heterocycl. Chem., 38, 1313-1315 (2001).
118. L. Wang and R. S. Hosmane, "A Unique Ring-Expanded Acyclic Nucleoside Analogue That Inhibits Both Adenosine Deaminase (ADA) and Guanine Deaminase (GDA; Guanase): Synthesis and Enzyme Inhibition Studies of 4,6-Diamino-8-H-1-hydroxyethoxymethyl-8-iminoimidazo[4,5-e][1,3]diazepine, " Bioorg. Med. Chem. Lett., 11, 2893-2896 (2001).
117. H. -M. Chen and R. S. Hosmane, "Synthesis of 1-(2'-O-Methyl-ß-D-ribofuranosyl)-1H-imidazo[4,5-d]pyridazine-4,7-
(5H, 6H) -dione: An Attractive Building Block for Antisense and Triple-helical Applications," Molecules, 6, 203- 207 (2001).
116. J. Gill, M. Bretner, R. Newman, N. Kyprianou, and R. S. Hosmane, "Synthesis, Anticancer Activity, and In Vitro
Mechanistic Investigations of Several "Fat" Nucleosides Containing the Imidazo[4,5-e][1,3] diazepine Ring System,"
Nucleosides & Nucleotides, 20, 1043-1045 (2001).
115. H. -M. Chen and R. S. Hosmane, "Acyclic Nucleoside/Nucleotide Analogues Bearing an Imidazole Ring Skeleton," Nucleosides & Nucleotides, 20, 1599-1614 (2001).
114. Z. Sun and R. S. Hosmane, "An Improved Synthesis of 9-Benzyladenine: A Model for Adenosine and Its Analogues," Synth. Commun., 32, 549-554 (2001).
113. R. K. Sood, V. S. Bhadti, H. -M. Chen, and R. S. Hosmane, "6-Amino-1-(2'-deoxy-b-D-ribofuranosyl)-4,5-dihydro-8H-imidazo[4,5-e][1,3]diazepine-4,8-dione," Molecules, 6, M264 (2001).
112. V. Rajappan and R. S. Hosmane, “A Model Study for a Novel Synthetic Approach to 2-Carboxyinosines,” Tetrahedron Letters, 41, 9713-9717 (2000).
111. H. -Chen and R. S. Hosmane, “6-Amino-2-phenylimidazo[4,5-e][1,3]diazepine-4,8(1H,5H)-dione,” Molecules, 6, M164 (2000)
110. S. Siddiqui and R. S. Hosmane, “Synthetic Analogue of Stilbene Containing an Imidazole Nucleus,” Molecules, 5, 856-863 (2000).
109. Z. Sun and R. S. Hosmane, “Photochromic Fulgides: Transformation of the Non-photochromic (Z)-Isomer of a Fulgide into a Highly Photochromic (E)-Isomer via Structural Modification Involving Enhanced Conjugation,” J. Heterocyclic Chemistry, 37, 1439-1441 (2000).
108 H.-M. Chen and R. S. Hosmane, “Synthesis of 1-(2'-Deoxy-b-D-ribofuranosyl)-1-H-imidazo[4,5-d]pyridazine-4,7(5H,6H)-dione: A Potential Building Block for Antisense Applications,” Molecules, 5, 1187-1193 (2000).
107. H.-M. Chen and R. S. Hosmane, “Synthesis of a Novel Ring‑Expanded Nucleoside Analogue Containing the Imidazo[4,5‑e][1,3]diazepine Ring System with a Guanidinocarbamoyl‑Substituted Cyclopropylidene Group in Place of a Sugar Moiety, ” J. Heterocyclic Chemistry, 37, 951-953 (2000).
106. M. Bretner, D. Beckett, R. Sood, and R. S. Hosmane, “Inhibition of Bacteriophage T7 RNA Polymerase by the 5'-Triphosphate Derivative of a Ring-Expanded (“Fat”) Nucleoside Possessing a Potent Anti-Hepatitis B Viral Activity,” Bioorg. Med. Chem., 7, 2931-2936 (1999).
105. J. Z. Dávalos, H. Flores, P. Jiménez, R. Notario, M. V. Roux, E. Juaristi, R. S. Hosmane, and J. F. Liebman, “Calorimetric, Calculational (G2(MP2) and G3) and Conceptual Study of the Energetics of the Isomeric 1,3- and 1,4-Dithianes,” J. Org. Chem., 64, 9328-9336 (1999).
104. M. Bretner, D. Beckett, and R. S. Hosmane, APotent Anti-Hepatitis B Viral Activity and Inhibition of Bacteriophage T7 RNA Polymerase by a “Fat” Nucleoside and Its 5'-Triphosphate Derivative: Synthetic, Biochemical, and Biological Studies of 4,8-Diamino-6-imino-6H-1-β-D-ribofuranosylimidazo[4,5-e][1,3]diazepine-5'-triphosphate,” Nucleosides & Nucleotides, 18, 837-838 (1999).
103. V. Rajappan and R. S. Hosmane, “Investigations into Biochemical Mode of Inhibition of Guanase by Azepinomycin: Synthesis and Biochemical Screening of Several Analogues of Azepinomycin,” Nucleosides & Nucleotides, 18, 835-836 (1999).
102. H. Chen, R. Sood, and R. S. Hosmane, “An Efficient, Short Synthesis of 6-Imino-6-H-1-β-D-ribofuranosyl-4,5,7,8-tetrahydroimidazo[4,5-e]diazepine-4,8-dione: A Novel Ring-Expanded Purine Nucleoside Analogue Containing a 5:7-Fused, Planar, Aromatic, Heterocyclic Ring System,” Nucleosides & Nucleotides, 18, 331-335 (1999).
101. S. P. Peri, V. S. Bhadti, R. Liang, R. S. Hosmane, and V. W. Macdonald, "Affinity Reagents for Cross-Linking Hemoglobin: Bis(phenoxycarbonylethyl)phosphinic Acid (BPCEP) and Bis(3-nitrophenoxycarbonylethyl)phosphinic Acid (BNCEP)," Hemoglobin, 23, 1-20 (1999).
100. V. Rajappan and R. S. Hosmane, “Synthesis and Guanase Inhibition Studies of a Ring-Expanded Purine Analogue Containing a 5:7-Fused, Planar, Aromatic Heterocyclic Ring System,” Bioorg. Med. Chem. Lett., 8, 3649-3652 (1998).
99. A. Skancke, R. S. Hosmane, and J. F. Liebman, "Unification of Some Literature Models of Aromaticity: A Calculational and Conceptual Study of a Set of One-Ring Species," Acta Chem. Scand., 52, 967-974 (1998).
98. Y. S. Agasimundin, M. W. Mumper, and R. S. Hosmane, "Inhibitors of Glycogen Phosphorylase B: Synthesis, Biochemical Screening, and Molecular Modeling Studies of Novel Analogues of Hydantocidin," Bioorg. Med. Chem., 6, 911-923 (1998).
97. V. P. Rajappan and R. S. Hosmane, "Analogues of Azepinomcin as Inhibitors of Guanase," Nucleosides & Nucleotides, 17, 1141-1151 (1998).
96. V. P. Rajappan and R. S. Hosmane, "Pentafluorophenol: A Superior Reagent for Condensations in Heterocyclic Chemistry," Synth. Commun. 28,753-764 (1998).
95. R. S. Hosmane, S. P. Peri, V. S. Bhadti, and V. W. Macdonald, "Bis[2-(4-carboxyphenoxy)carbonylethyl]phosphinic Acid (BCCEP): A Novel Affinity Reagent for the β-Cleft Modification of Human Hemoglobin," Bioorg. Med. Chem., 6, 767-783 (1998).
94. R. S. Hosmane and M. Hong, "How Important Is the N-3 Sugar Moiety in the Tight-Binding Interaction of Coformycin with Adenosine Deaminase?" Biochem. Biophys. Res. Commun., 236, 88-93 (1997).
93. F. N. Burnett and R. S. Hosmane, "Imidazo[4,5-e][1,2,4]triazocine: A Novel 5:8-Fused Ring System Riddled with Rearrangements," Heterocycles, 45, 857-861 (1997).
92. M. V. Roux, P. Jimênez, M. À. Martín-Luengo, J. Z. Dàvalos, Z. Sun, R. S. Hosmane, J. F. Liebman, "The Elusive Antiaromaticity of Maleimides and Maleic Anhydride: Enthalpies of Formation of N-Methylmaleimide, N-Methylsuccinimide, N-Methylphthalimide and N-Benzoyl-N-methylbenzamide," J. Org. Chem., 62, 2732-2737 (1997).
91. M. Hong and R. S. Hosmane, "Irreversible, Tight-Binding Inhibition of Adenosine Deaminase by Coformycins: Inhibitor Structural Features that Contribute to the Mode of Inhibition, " Nucleosides and Nucleotides 16, 1053-1057 (1997).
90. S. P. Peri, V. S. Bhadti, R. S. Hosmane, and V. W. Macdonald, "Bis[2-(4-carboxyphenoxy)carbonylethyl)phosphinic Acid (BCCEP): A New Reagent for Hemoglobin Modification," Artif. Cells Blood Subs. Immobil. Biotech. 25, 511-520 (1997).
89. V. S. Bhadti, S. P. Peri, and R. S. Hosmane, "A Novel Organic Reagent for Biomacromolecular Modification: Bis(Phenoxycarbonylethyl)phosphinic Acid," Bioorg. Med. Chem. Lett. 6, 879-882 (1996).
88. S. Pou, A. Bhan, V. S. Bhadti, S. Y. Wu, R. S. Hosmane, and G. M. Rosen, " The Use of Fluorophore-Containing Spin Traps as Potential Probes to Localize Free Radicals in Cells with Fluorescence Imaging Methods," The FASEB Journal, 9, 1085-1090 (1995).
87. Z. Sun, R. S. Hosmane, and M. Tadros, "Fulgides and Photochromism. Synthesis of 5-Dicyanomethylene-4-dicyclopropylmethylene 3-(2,5-dimethyl-3-furylethylidene) tetrahydrofuran-2-one," Tetrahedron Lett., 36, 3453-3456 (1995).
86. Z. Sun, R. S. Hosmane, M. Tadros, S. Guha, W. Chen, and J. Chen, "Photochromism of Fulgides and Stereoelectronic Factors. Synthesis of 4-Adamantylidene-5-dicyanomethylene-3-[2,5-dimethylfurylethylidene)tetrahydrofuran-2-one and (E)- and (Z)-4-Adamantylidene-3-[2,6-dimethyl-3,5-bis(p-dimethylaminostyryl)benzylidene]tetra-hydrofuran-2,5-dione," J. Heterocycl. Chem., 32, 1819-1828 (1995).
85. P. R. Rao, S. Jones, Z. Sun, R. S. Hosmane, O. Abugo, and J. Rifkind, "Aspirin Analogues and Flow of Erythrocytes through Narrow Capillaries," Clin. Hemorheol., 15, 877-887 (1995).
84. A. Bhan, R. S. Hosmane, H. Zhang, and N. S. Hosmane, "A Diaminomalonate Synthon Useful for Building Novel Heterocycles," Synth. Commun., 25, 2723-2737 (1995).
83. F. N. Burnett, B. B. Lim, and R. S. Hosmane, "Synthetic Approaches to 5:8-Fused Heterocyclic Systems. A Novel rearrangement During the Synthesis of Imidazo[4,5-e][1,2,4]triazocine Ring System," Nucleosides and Nucleotides, 14, 325-328 (1995).
82. A. Bhan and R. S. Hosmane, "Analogues of Azepinomycin: Inhibitors of Guanase," Nucleosides and Nucleotides, 14 , 455-458 (1995).
81. L. Wang, A. Bhan, and R. S. Hosmane, "A Short Synthesis of a Novel Ring-Expanded Purine and Its Nucleoside Analogue Containing the Imidazo[4,5-e][1,3]diazepine Ring Skeleton with Multiple Amino Substituents Attached to the 7-Membered Ring," Nucleosides and Nucleotides, 13, 2307-2320 (1994).
80. A. Bhan and R. S. Hosmane, "Novel Inhibitors of Guanase," Tetrahedron Lett., 35, 6831-6834 (1994).
79. C. M. Bertha, R. S. Hosmane, H. Zhang, and N. S. Hosmane, "Reagents for Bioorganic Synthesis. 6. The Design and Synthesis of Two Novel Polyfunctional Organic Reagents for Biomacromolecular Modification," J. Biomol. Struct. Dyn., 12, 413-437 (1994).
78. M.W. Mumper, C. Aurenge, and R. S. Hosmane, "'Slim' Nucleosides and Nucleotides. I. Synthetic, Structural, and Biophysical Investigations of Showdomycins," J. Biomol. Struct. Dynamics, 11, 1107-1131 (1994).,
77. A. Bhan, R. S. Hosmane, H. Zhang, and N. S. Hosmane, "Ring Closure of Diethyl 2-Methoxy-2-[N-(5-amino-1-benzylimidazolyl-4-carbonyl)amino]malonate: Product Structures and Pathways of Product Formation" Struct. Chem., 5, 375-381 (1994).
76. M. W. Mumper, C. Aurenge, and R. S. Hosmane, "A Short, Convenient Synthesis of 2'-Deoxyshowdomycin," Bioorg. Med. Chem. Lett., 3, 2847-2850 (1993).
75. A. Bhan and R. S. Hosmane," Reactions of Ring-Expanded Xanthines Containing the Imidazo[4,5-e][1,4]diazepine Ring Systems," J. Heterocyclic Chem., 30, 1453-1462 (1993).
74. S. Pou, A. Bhan, V. S. Bhadti, S. Y. Wu, R. S. Hosmane, and G. M. Rosen, "Synthesis of Fluorophore Containing Nitroxides for Detecting Superoxide and Hydroxyl Radical Generated by Stimulated Neutrophils," Anal. Biochem., 212, 85-90 (1993).
73. V. P. Vaidya, R. S. Hosmane, U. Siriwardane, H. Zhang, and N. S. Hosmane, "Unequivocal Structural Assignment of the Product of Methylation of 4-Nitro-5-styrylimidazole," Struct. Chem., 4, 339-343 (1993).
72. C. M. Bertha, R. S. Hosmane, H. Zhang, and N. S. Hosmane, "Reagents for Biooganic Synthesis. 5. The Synthesis of Two Potential Cross-Linking Reagents: 2,2'-Sulfonylbis[3-benzylamino-(E,E)-N-(2-oxoethyl)propenamide and 2,2'-Sulfonylbis[3-benzylamino-(E,E)-N-(2-chloroethyl)propenamide," J. Org. Chem., 57, 5868-73 (1992).
71. C.. M. Bertha and R. S. Hosmane, "The Synthesis of a Potential Cross-Linking Reagent: 2,2'-Sulfonylbis[3-benzylamino-(E,E)-N-(2-oxoethyl)propenamide," Tetrahedron Lett., 33, 3425-3428 (1992).
70. R. S. Hosmane and J. F. Liebman, "Aromaticity of Five-Membered Heterocycles: An Experimentally Convenient Theoretical Model for Prediction of Relative Aromaticity," Tetrahedron Lett., 33, 2303-2306 (1992).
69. V.S. Bhadti, A. Bhan, and R. S. Hosmane, "The synthesis of Novel Regioisomeric Ring-expanded Xanthine Nucleosides Containing the 5:7-Fused Imidazo[4,5-e][1,2,4]triazepine Ring System," Nucleosides and Nucleotides, 11, 1137-1149 (1992).
68. A. Bhan and R. S. Hosmane, "The Synthesis, Structure, and Conformation of 2'-Deoxy Analogues of "Fat" Xanthine Nucleosides Containing the Imidazo[4,5-e][1,4]diazepine Ring System," Nucleosides and Nucleotides, 11, 1175-1200 (1992).
67. R.S. Hosmane and J.F. Liebman, "Aromaticity of Heterocycles: Experimental Realization of Dewar-Breslow Definition of Aromaticity," Tetrahedron Lett. 3949-3952 (1991).
66. R.S. Hosmane, V.P. Vaidya, M.K. Chung, U. Siriwardane, and N.S. Hosmane, "Synthesis of Ring-expanded Xanthines and Xanthosines Containing the Imidazo[4,5-d][1,3]diazepine Ring System," Nucleosides and Nucleotides 10, 1693-1706 (1991).
65. R.S. Hosmane and B.B. Lim, "The Synthesis and Structure of 1,2,3,4-Tetrahydro-8-nitroimidazo[1,5-d][1,2,4]triazin-1-one, C8H11N5O3: A Heterocycle with a Rare Ring System," J. Cryst. Spectr. Res. 21, 353-356 (1991).
64. R.S. Hosmane, A. Bhan, M. Hulce, H.M. Zhang, and N.S. Hosmane, "Synthetic, Structural, and Conformational Studies of Methylated Ring-expanded Nucleosides C ontaining the Imidazo[4,5-e][1,4]diazepine Ring System," Nucleosides and Nucleotides 10, 819-836 (1991).
63. R.S. Hosmane and A. Bhan, "The Synthesis of Ring-expanded Analogues of Xanthine, Containing the Imidazo[4,5-e][1,4]diazepine Ring System," J. Heterocycl. Chem. 27, 2189-2196 (1990).
62. R.S. Hosmane and C.M. Bertha, "Bifunct. Reag. for Bioorg. Synth. Bis-enamines. Cross-linking by Amine Exch. Reactions," Synth. Commun. 20, 2921-2935 (1990).
61. R.S. Hosmane, A. Bhan, R.L. Karpel, U. Siriwardane, and N.S. Hosmane, "The Synthesis and Biophysical Investigations of Novel Ring-expanded Nucleosides, Nucleotides, and Homopolymers Containing the 5:7-Fused Heterocyclic Ring System, Imidazo[4,5‑e][1,4]- diazepine," J. Org. Chem. 55, 5882-5890 (1990).
60. R.S. Hosmane, V.S. Bhadti, and B.B. Lim, "Synthesis of a Novel Ring-Expanded Xanthine Analogue and Its Several Methyl or Benzyl Derivatives, Containing the 5:7-Fused Imidazo[4,5-e][1,2,4]triazepine Ring System," Synthesis 1095-1100 (1990).
59. R.S. Hosmane and A. Bhan, "The Synthesis of Two Novel Ring-Expanded Xanthine Nucleosides Containing the Imidazo[4,5-e][1,4]diazepine Ring System," Nucleosides and Nucleotides 9, 913-922 (1990).
58. R.S. Hosmane, C.M. Bertha, U. Siriwardane, and N.S. Hosmane, "Reagents for Bioorganic Synthesis. 4. Preparation, Structure, Properties, and Reactions of 2,2'‑Sulfonylbis[3-methoxy-(E,E)-2-propenenitrile]," J. Org. Chem. 55, 5206-5216 (1990).
57. R.S. Hosmane and C.M. Bertha, "A Versatile, Highly Reactive, Cross-Linking Reagent: 2,2'-Sulfonylbis[3-methoxy-(E,E)-2-propenenitrile]," Biochem. Biophys. Res. Commun. 166, 567-573 (1990).
56. R.S. Hosmane and A. Bhan, "Conformational Studies of Two Isomeric Ring-expanded Purine Nucleosides and their 5'-Mono- and -Diphosphate Derivatives," Biochem. Biophys. Res. Commun. 165, 106-113 (1989).
55. R.S. Hosmane, B.B. Lim, M.F. Summers, U. Siriwardane, N.S. Hosmane, and S.C. Chu, "Rearrangements in Heterocyclic Synthesis. 2. Novel Transformations of 2‑Aminonicotino‑ and Anthranilonitriles," J. Org. Chem., 53, 5309-5315 (1988).
54. R.S. Hosmane and C.M. Bertha, "A Novel Bifunctional Reagent: 2,2'‑Methoxymethylene‑2,2'‑bis‑acetonitrile," Tetrahedron Lett. 29, 5847-5850 (1988).
53. U. Siriwardane, S.C. Chu, N.S. Hosmane, C.M. Bertha, and R.S. Hosmane, "Structure of a Potential Cross‑linking Reagent: 2,2'‑Methoxymethylene‑2,2'‑sulfonyl‑bis‑ acetonitrile (MMSBA)," Acta Cryst., C44, 104-107 (1988).
52. R.S. Hosmane and B.B. Lim, "Chemistry of the 5:7‑Fused Heteroaromatic Systems: A Novel Rearrangement Involving the Imidazo[4,5‑e][1,3,4]triazepine and Pyrazolo[3,4‑e][1,3,4]triazepine Systems," Heterocycles, 27, 31-34 (1988).
51. R.S. Hosmane, B.B. Lim and F.N. Burnett, "Rearrangements in Heterocyclic Synthesis: A Novel Translocation of an (N‑Amino‑N‑methyl)formamidine Side‑chain to the Vinylogous Nitrile Function" J. Org. Chem. 53, 382-386 (1988).
50. R.S. Hosmane and B.B. Lim, "A Novel Method for the Synthesis of 6‑(ß‑methyl)hydrazinopurine and 4‑(ß‑methyl)hydrazinopyrazolo[3,4d]pyrimidine, Synthesis 242-244 (1988).
49. C. Afshar, H.M. Berman, P. Sawzik, L. Lessinger, B.B. Lim, and R.S. Hosmane, "Structure of an Unexpected Product, [1‑Methyl‑3‑(5‑amino‑1benzylimidazol‑4‑yl)‑ 1,2,4‑triazole], C13H14N6," J. Cryst. Spec. Res., 17, 533-543 (1987).
48. U. Siriwardane, N.S. Hosmane, S.C. Chu, C.M. Bertha, and R.S. Hosmane, "Structure of a Bifunctional Organic Reagent: 2,2'‑Bis(dimethylaminomethylene)‑2,2'‑ sulfonyldiacetonitrile," Acta Cryst., C43, 1823-1826 (1987).
47. U. Siriwardane, N. S. Hosmane, S. S. C. Chu, and R. S. Hosmane, “1-(2,2´-Bipyridyl)-2-(methyl)-3-(trimethylsilyl)-2,3-dicarba-1-stanna-closo-heptaborane(6),” Acta Cryst., Cryst. Struct. Commun. 1987, C43, 1067-1069.
46. R.S. Hosmane, A. Bhan, and M.E. Rauser, "Models for "Fat" Nucleosides and Nucleotides: Syntheses of "Fat" Xanthine (fX), "Fat" Guanine (fG), and "Fat" Hypoxanthine (fHx) Analogues of the Imidazo[4,5‑e][1,4]diazepine System," Heterocycles, 24, 2743-2748 (1986).
45. R.S. Hosmane and B.B. Lim, "A General Method for the Synthesis of 1‑Substituted (or Unsubstituted)‑4‑carbomethoxy‑2‑imidazolin‑5‑ones," Tetrahedron Lett. 26, 1915-1918 (1985).
44. B.B. Lim and R.S Hosmane, "Reagents for Bioorganic Synthesis II: Methyl N‑(Dicarbomethoxymethyl)methanimidate," J. Org. Chem. 50, 5111-5115 (1985).
43. R.S. Hosmane and B.B. Lim, "On the Mechanism of the One‑Pot Conversion of 4‑Carbomethoxy‑5‑hydroxyimidazoles into 5‑amino‑4‑carbamoylimidazoles," Heterocycles, 23, 2247-2250 (1985).
27. R.S. Hosmane, A. Bhan, and M.E. Rauser, "Facile Conversion of o‑Nitro Methylimidazoles into o‑Nitro Cyanoimidazoles", J. Org. Chem., 50, 5892-5895 (1985).
26. R.S. Hosmane, F.N. Burnett, and M.S. Albert, "Reagents for Bio‑organic Synthesis: Preparation, Properties and Reactions of Ethyl and Methyl N‑Cyanomethylmethanimidates," J. Org. Chem., 49, 1212-1215 (1984).
25. R.S. Hosmane, "Imidates in Organic Synth.: Methyl N‑Cyanomethylmethanimidate," Tetrahedron Lett., 25, 363-366 (1984).
24. R.S. Hosmane, "An Efficient, One‑Step Synthesis of 2‑Imidazolin‑4(5)one," Liebigs Ann. Chem., 831-834 (1984).
23. M. Shahbaz, S. Urano, P.L. LeBreton, M.A. Rossman, R.S. Hosmane, and N.J. Leonard, "Synthesis, Chemical Behavior, and Spectroscopic and Theoretical Probes of Valence Orbital Structure," J. Am. Chem. Soc., 106, 2805-2811 (1984).
22. S.W. Schneller, J. ‑K. Luo, R.S. Hosmane, and R.H. Durrfeld, "The Synthesis of 1‑Substituted 6‑Amino‑1H‑pyrrolo[3,2‑c]-pyridin‑4(SH)ones," J. Heterocycl. Chem., 21, 1153-1155 (1984).
21. S.W. Schneller, J. ‑K. Luo, R.S. Hosmane, R. Durrfeld, E. DeClercq, J.D. Stoeckler, K.C. Agarwal, R.E. Parks, Jr. and P.P. Saunders, "Synthesis and Biological Evalution of 6‑Amino‑1H‑pyrrolo[3,2‑c]pyridin‑4(5H)‑one(3,7‑Dideazaguanine), J. Med. Chem., 27, 1737-1739 (1984).
20. A. Halpern, M.A. Rossman, R.S. Hosmane, and N.J. Leonard, "The Photophysics of the S1S0 Transition in Tri‑s-triazine," J. Phys. Chem., 88, 4324-4326 (1984).
19. N.J. Leonard, R.S. Hosmane, Y.S. Agasimundin, L.J. Kostuba, and F.T. Oakes, "Chemical Modification of Nucleic Acid Components: Conversion of Guanosine by Methyl N‑Cyanomethanimidate to a Tricyclic, Fluorescence Analogue of Adenosine," J. Am. Chem. Soc., 106, 6847-6848 (1984).
18. R. Balicki, R.S. Hosmane, and N.J. Leonard, "Translocative Rearrangements. Generality of Formanidine‑induced Rearrangement of 4‑Substituted 5‑Amino‑4‑cyano‑4H‑imidazoles", J. Org. Chem., 48, 3-7 (1983).
17. R.S. Hosmane, V. Bakthavachalam, and N.J. Leonard, "5‑Methyl‑adenine: A Transient Intermediate in a Translocative Rearrangement," J. Am. Chem. Soc., 104, 235-239 (1982).
16. R.S. Hosmane, M.A. Rossman, and N.J. Leonard, "Synthesis and Structure of Tri‑s‑triazine," J. Am. Chem. Soc., 104, 5497-5499 (1982).
15. R.S. Hosmane, and N.J. Leonard,"Chemical Modification of Nucleic Acid Components: Reactions of Cytosine, Cytidine, Isocytosine, and Adenine with Methyl N‑Cyanomethanimidate," J. Org. Chem., 46, 1457-1465 (1981).
14. R.S. Hosmane, and N.J. Leonard, "Simple, Convenient Synthesis of 1‑Methylcytosine," Synthesis, 118-119 (1981).
13. D.L. Helfer, R.S. Hosmane, and N.J. Leonard, "Selective Alkylation (Aralkylation) of Cytosine at the 1‑Postion," J. Org. Chem., 46, 4803-4804 (1981).
12. S.W. Schneller, J. ‑K. Luo, and R.S. Hosmane, "Synthesis of 3,7‑Dideazaguanine," Tetrahedron Lett., 21, 3135-3138 (1980).
11. S.W. Schneller, and R.S. Hosmane,"Pyrrolo[3,2‑c]pyridin-4,6(5H,7H)dione (3,7‑Dideazaxanthine)" in "Nucleic Acid Chemistry Improved and New Sythetic Procedures, Methods and Techniques," Part I, L.B. Townsend and R.S. Tipson, Ed., John‑Wiley, New York, N.Y., 1978; p. 137.
10. S.W. Schneller and R.S. Hosmane, "Ring Opening Reactions of 3,7‑Dideazaxanthine, 1‑Methyl‑3,7‑Dideazaxanthine and 1‑Oxa‑3,7‑Dideazaxanthine," J. Org. Chem., 43, 4487-4491 (1978).
9. S.W. Schneller, R.S. Hosmane, L.B. McCartney and D.A. Hessinger, "Synthesis and Xanthine Oxidase Inhibitory Activity of 3,7‑Dideazaxanthine and Two of Its Derivatives," J. Med. Chem., 21, 990-993 (1978).
8. S.W. Schneller, and R.S. Hosmane, "Synthesis of 3,7‑Dideaza isoguanine," J. Heterocycl. Chem., 15, 1505-1506 (1978).
7. S.W. Schneller, and R.S. Hosmane, "Chlorination of 3,7‑Dideazaxanthine and Its 1‑Methyl Derivative," J. Heterocycl. Chem., 15, 325-326 (1978).
6. S.W. Schneller, and R.S. Hosmane, "Pyrrolo[3,2‑c]pyridin‑4,6(5H,7H)dione(3,7‑Dideazaxanthine)," J. Heterocycl. Chem., 14, 1291-1292 (1977).
5. R.S. Hosmane, S.P. Hiremath and S.W. Schneller, "Synthesis of tryptamine Analogs of 3H‑benz[e]‑ and 1H‑Benz[g]indole," Indian J. Chem., 12, 1009-1011 (1974).
4. R.S. Hosmane, S.P. Hiremath and S.W. Schneller, "Synthesis of Benz[e]indole and Benz[g]indole Carboxaldehydes," J. Heterocycl. Chem., 11, 29-32 (1974).
3. R.S. Hosmane, S.P. Hiremath and S.W. Schneller, "Synthesis of Indoles and Carbazoles: Diels‑Alder Reactions of Nitrovinylpyrroles and benzindoles," J. Chem. Soc., Perkin Trans. I, 2450-2453 (1973).
2. S.P. Hiremath, and R.S. Hosmane, "Applications of Nuclear Magnetic Resonance Spectroscopy to Heterocyclic Chemistry: Indole and Its Derivatives," Adv. Heterocycl. Chem., 15, 277-300 (1973).
1. S.P. Hiremath, and R.S. Hosmane, "Use of Physical Methods in Heterocyclic Chemistry ‑ Part I. Nuclear Magnetic Resonance Spectroscopy," J. Karnatak Univ. (Science), 14, 202-226 (1969).